R 1524
Voclosporin
CAS: 515814-01-4
Molecular Formula: C63H111N11O12
R 1524 - Names and Identifiers
R 1524 - Physico-chemical Properties
| Molecular Formula | C63H111N11O12 |
| Molar Mass | 1214.65 |
| Density | 1.016±0.06 g/cm3(Predicted) |
| Boling Point | 1303.8±65.0 °C(Predicted) |
| pKa | 13.32±0.70(Predicted) |
R 1524 - Uses and synthesis methods
biological activity
Voclosporin (ISAtx-247) is a calcineurin (CN; PP2B) inhibitor.
target
Calcineurin
in vitro study
This novel semi-synthetic calcineurin (CN) inhibitor is designated Voclosporin (ISATX247). The efficacy of Voclosporin as an immunosuppressive agent is examined using an in vitro calcineurin assay. Voclosporin (ISATX247) is a calcineurin inhibitor that has shown more potency than Cyclosporine in vitro.
in vivo studies
All animals tolerate Voclosporin (ISATX247) and Cyclosporine A (CsA) very well. There are no severe adverse effects associated with either drug. In the Voclosporin group, all animals except 1 have diarrhea of different durations during the study (mean 2.3 days, range 2 to 7 days). This differs from the CsA and the control groups, where no animals have diarrhea. Mean weight loss at the end of the study is slightly higher in the Voclosporin group than in the CsA and control groups (3.4% vs 2.0% and 1.0%, respectively).
Last Update：2024-04-09 01:59:50
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Tel: 0712-8899838
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Spot supply
Product Name: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone Request for quotationCAS: 515814-01-4
Tel: 400-968-2212
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Mobile: 18916960931
QQ: 3623107365
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Product Name: Voclosporin Visit Supplier Webpage Request for quotationCAS: 515814-01-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Voclosporin Visit Supplier Webpage Request for quotationCAS: 515814-01-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: ISAtx-247 Visit Supplier Webpage Request for quotationCAS: 515814-01-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
View History
R 1524
DECAMETHYLMANGANOCENE
INDIUM(III) TRIFLATE
PNP ALPHA-D-XYLOPYRANOSIDE
DIETHYLHEXYL BUTAMIDO TRIAZONE
C.I. Sulphur Yellow 9
DECAMETHYLMANGANOCENE
INDIUM(III) TRIFLATE
PNP ALPHA-D-XYLOPYRANOSIDE
DIETHYLHEXYL BUTAMIDO TRIAZONE
C.I. Sulphur Yellow 9